All Days; Fri, Nov 6 ; Full Schedule - 2020 ACR Convergence. Ashvattha Therapeutics, a clinical-stage biotech company focused on … Program and Faculty are updated daily - check back often for the most up-to-date information. There were many studies that addressed “pre-PsA,” similar to pre-RA in patients with some arthralgias and a positive cyclic citrullinated peptide (CCP) test. So, symmetric vs asymmetric sacroiliitis and thin vs chunky syndesmophytes would be 1 way of differentiating between axial PsA and axial SpA. Runci Wang, MD, PhD; Karmela Kim Chan, MD; Amy Cunningham-Bussel, MD; Gregory Vitone; Aidan Tirpack; Caroline Benson; Gregory Keras; Anna Helena Jonsson, MD, PhD; Michael Brenner, MD; Laura Donlin, PhD; Anne Bass, MD; Deepak A. Rao, MD, PhD. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. ACR CONVERGENCE 2020— Earlier this year, the ACR released an updated guideline for the management of gout, and approximately 50 abstracts of studies on various aspects of gout were accepted for presentation at ACR Convergence 2020. However, radiographic examination of these patients will demonstrate symmetric sacroiliitis. Home of the insider insights newsletter and the Canadian Insider Club which offers alerts and premium research. The investigators also looked at enthesitis resolution, minimal disease activity, and Health Assessment Questionnaire Disability Index. We hope you’re enjoying the latest clinical news, full-length features, case studies, and more. It is thought that IL-23 inhibitors have no effect on the axial skeleton based on 2 studies: the first one included risankizumab, another IL-23 p19 inhibitor, and the second one was on ustekinumab, an IL-12/23 inhibitor. Registration is free. “If we heed these lessons and implement change thoughtfully, rheumatology will enter a new era as an even more essential and highly sought-after specialty,” she said in her speech. They also evaluated individual components of BASDAI.4 These findings are quite interesting and make us think that perhaps axial PsA is different than axial SpA. Researchers of the 2 guselkumab 1-year trials pooled data and studied patients who had axial symptoms and evidence of imaging-based sacroiliitis. Shared decision-making is very important. These “checkpoint inhibitor” therapies can unleash a powerful immune response against tumors but can also induce unintended autoimmune responses, including inflammatory arthritis. Minimal disease activity with filgotinib was found to be about 31% at week 100.3. The increasing availability of detailed electronic health record data, along with methods such as machine learning and natural language processing (NLP), provide an opportunity to streamline our ability to find these patients. Efficacy of upadacitinib in patients with psoriatic arthritis stratified by number of prior biologic disease-modifying anti-rheumatic drugs. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. TNF is a key mediator of bone loss, not only through promotion of osteoclasts (bone-resorbing cells), but also through inhibition of osteoblast (bone-forming cells) function. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . All times listed are Eastern Standard Time. The real clinical question is how to differentiate between a patient who has ankylosing spondylitis (AS) with skin psoriasis and a patient who has PsA and axial symptoms. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; ACR Convergence 2020 . Approximately 80% of patients with AS have the HLA-B27 gene, and only approximately 50% of patients with axial PsA have the HLA-B27. This site features news for physicians about research, innovation and clinical care at Brigham and Women’s Hospital. Jessica N. Williams, MD, MPH; Kreager Taber; Candace H. Feldman, MD. Abstract 907. If it is more severe and there is involvement of numerous joints with polyarticular inflammation and skin involvement, you directly use a TNF inhibitor and avoid methotrexate. Type here to filter the list. There are also several types of drugs and there are many different classes of each drug: conventional synthetic disease-modifying antirheumatic drugs (DMARDs); TNF inhibitors (there are 5 of them); the IL-12/23 inhibitor (ustekinumab); IL-17 inhibitors (secukinumab and ixekizumab); pure IL-23 inhibitors (there are 3 of them; 1 has been approved for PsA [guselkumab], but rizankizumab and tildrakizumab are being studied in phase 2 trials presented at the ACR 2020 meeting); JAK inhibitors; the phosphodiesterase-4 (PDE4) inhibitor apremilast; and abatacept (a T-cell inhibitor that is mainly used for RA but has been approved for the treatment of PsA). Important Dates . According to the ACR-NPF treatment guidelines, which are a significant departure from older treatment guidelines and EULAR recommendations, patients with severe disease can directly receive a TNF inhibitor. Investigators said efficacy response rates at week 78 were 84.2% for all patients, and 83.4%, 85.8%, and 84.3% for the biosimilar, week 26 switch, and week 52 switch groups, respectively. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . At the ACR Convergence 2020, updated findings were presented for weeks 52 to 92 in patients who continued ADL-PF (N = 552). Disclosure: Dr Atul A. Deodhar declared affiliations with the pharmaceutical industry. Two long-time Brigham rheumatologists also received prestigious honors. Guselkumab, an interleukin (IL)-23 p19 inhibitor, has been effective in PsA, as demonstrated by the results of phase 2 and phase 3 studies published in the Lancet. All times listed are Eastern Standard Time. There was another presentation at ACR 2020 on whether there are risk factors in patients with skin psoriasis who develop PsA. This team targeted schnurri3 (Shn3) — a large, intracellular protein upregulated by TNF and IL-17A and known to be a suppressor of osteoblast activity — in specific bone cells in several mouse models of RA and determined its therapeutic potential in RA-induced bone loss. I’ll be covering these topics, and discussing select individual posters and abstracts during this meeting. Convergence 2020 highlighted several important treatment abstracts related to systemic lupus erythematosus. In axial PsA, patients typically have asymmetric sacroiliitis and “chunky,” asymmetric, osteophyte-looking changes in the spine that run from the middle of the vertebra to the next vertebra. They assessed changes in BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), and, when guselkumab was compared to placebo, there was a statistically significant difference. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Welcome to the ACR/ARP Abstracts … Dr Saakshi Khattri reviews key abstracts about psoriatic arthritis from the annual ACR meeting, including a tool for early detection and a study showing dactylitis may signal an aggressive phenotype. Ashvattha Therapeutics Selected to Present Virtual Poster at ACR Convergence 2020. These investigators recently reported that a key step in pannus formation and fibroblast expansion in RA is driven by endothelial-derived Notch signaling. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1460 “Can I … The ACR abstracts are available online at the conference website . - Drug Monographs However, there are several clinical, genetic, and radiographic differences between axial PsA and axial SpA, and this is an active area of research. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. However, one has to take this with a “pinch of salt” when one is looking at clinical trials that assess safety, as longer-term follow-up in postmarketing experience is needed. Your use of this website constitutes acceptance of Haymarket Media’s Privacy Policy and Terms & Conditions. Thanks for visiting Rheumatology Advisor. Program and Faculty are updated daily - check back often for the most up-to-date information. Accepted Late-Breaking abstracts will be available late October. Michael B. Brenner, MD, was named an ACR Master, which recognizes “outstanding contributions to the ACR and the field of rheumatology through scholarly achievement and/or service to their patients, students, and profession.” In addition, Daniel Hal Solomon, MD, MPH, was given the Excellence in Investigative Mentoring Award, which honors “contributions to the rheumatology profession through outstanding and ongoing mentoring.”. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. “We hope that by understanding the similarities and differences between immune cells in different types of inflammatory arthritis, including checkpoint inhibitor-associated arthritis, we can identify specific signals that block the key pathologic signals in each condition,” Dr. Rao said. The study found no difference between the combination treatment and etanercept alone. Dr. Liao’s team developed an algorithm using machine learning and NLP that reduced the number of charts requiring review by 40–45 percent compared to reviewing any subjects with an ICD code for rheumatoid arthritis (RA). One of the new agents for PsA is upadacitinib. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster presentations. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you The ACR abstracts are available online at the conference website.Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. If the disease is mild, you can use methotrexate. I might then consider the IL-12/23 inhibitor ustekinumab because that drug has been in the market for quite some time and it is a very good drug with respect to the skin, although in my experience it is not as good a drug as TNF inhibitors for the joints. Presented at: ACR Convergence 2020; November 5-9, 2020. The ACR50/70 responses with deucravacitinib 6 and 12 mg per day administered orally were found to be superior to placebo. … There is a hierarchy to follow depending on the severity of the patient’s PsA. … What was reported at the ACR 2020 meeting was the effect of guselkumab on axial disease in PsA. They also aimed to understand whether social determinants of health-related needs such as food insecurity, housing instability and financial constraints were prevalent among patients with lupus enrolled in iCMP. These data were presented earlier at EULAR 2020, but this was the first time they were presented at ACR. Investigators examined whether iCMP was effective at decreasing the incidence rates of ED visits, hospitalizations and outpatient appointment no-shows. here. Accepted general abstracts from ACR Convergence 2020 can be searched and viewed online starting late September. Coates L, Gladman D, Van de Bosch F, et al. The researchers indicated that methotrexate seems to have good efficacy in PsA, although the study had limitations because there was no placebo and it could be claimed that the methotrexate response was because of the placebo. The surprise was that compared to adalimumab, which is a very good drug even for the skin, the response rate (Psoriasis Area and Severity Index [PASI] 90, PASI 100) with upadacitinib was found to be better than with adalimumab.1, The other abstract addressed upadacitinib in patients with inadequate response to TNF inhibitors; this study showed that patients with PsA demonstrated a good response to upadacitinib.2, Long-term data (week 52 and 100) from a study on another JAK1 inhibitor, filgotinib, showed that this drug works and maintains its efficacy in the long term. Long-term outcomes with filgotinib, an oral selective Janus kinase 1 inhibitor: 100-week data from an open-label extension (OLE) study in patients with active psoriatic arthritis (PsA). Highlights of Abstracts From ACR Convergence 2020. Abstract 907. - Conference Coverage A nurse-led integrated care management program (iCMP) aims to coordinate medical care and to uncover and address social determinants of health-related needs for medically and psychosocially complex patients at high risk for frequent emergency department visits and hospitalizations. As I mentioned earlier, there are head-to-head studies showing that IL-17 inhibitors are as effective as TNF inhibitors; they are noninferior and superior in the skin. Dr. Rao led a team that used mass cytometry immunophenotyping to study the immune cells that accumulate in joint fluid of patients who develop inflammatory arthritis following anti-PD-1 therapy. In clinical practice, my decision will depend on how severe the patient’s musculoskeletal disease and skin disease are. Results of the SEAM study (Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis; ClinicalTrials.gov Identifier: NCT02376790) were published last year and presented at the 2019 ACR annual meeting. Program and Faculty are updated daily - check back often for the most up-to-date information. In this study, the team performed single-cell transcriptomic analysis (scRNAseq) of synovial vasculature to characterize vascular remodeling at a single-cell level. Get stock quotes, news, fundamentals and easy to read SEC and SEDI insider filings. Therapies to induce immune responses against tumors, such as anti-PD-1 antibodies, have revolutionized the treatment of many cancers. Type here to filter the list. There is a lot of work being conducted on standardizing the terminology for pre-PsA. Watts, MSc; Trinn Major, PhD; Zhu, MSc; Yuhong Li, MSc; Christopher Buckley, MBBS; Soumya Raychaudhuri, MD, PhD; Michael B. Brenner, MD. Post was not sent - check your email addresses! If these patients have syndesmophytes, they are thin and run from the lower end of a vertebra to the upper end of the lower vertebra. At week 52, all patients remaining on ADL-EU were switched to ADL-PF. If a patient has not responded to treatment with 1 or more TNF inhibitors, then I would probably use IL-17 inhibitors first, only because they have a longer track record compared to the JAK inhibitors. So, this is another new and interesting class of drugs that we can look forward to. The work provided promising evidence that targeting this pathway could be a novel therapeutic strategy for both systemic and joint-based RA-induced bone loss. “The Brigham’s Division of Rheumatology, Inflammation, and Immunity provided an important scientific presence at the meeting, and many division members served as moderators and session leaders, contributing significantly to the meeting’s impact and success.”. The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. For PsA, we do not have any antibodies such as rheumatoid factor or anti-CCP. One would also take into account whether there is significant skin involvement, as we know that IL-17 and IL-23 inhibitors are superior to TNF inhibitors with respect to the skin. If you wish to read unlimited content, please log in or register below. Mease P, Helliwell P, Gladwell D, et al. Presented at: ACR Convergence 2020; November 5-9, 2020. Mease P, Deodhar A, van der Heijde D, et al. In this case, as well, it wasn’t any different that upadacitinib worked well on the musculoskeletal component of PsA. Haberman R, Perez-Chada L, Chandran V, et al. At 1 year, predictors of development of PsA included arthralgia, joint aches and pains, and fatigue. Type here to filter the list. Presented at: ACR Convergence 2020; November 5-9, 2020. Ellen M. Gravallese, MD, chief of the Brigham’s Division of Rheumatology, Inflammation, and Immunity, gave the Presidential Address upon completion of her term as ACR president, expounding on the inspiring response of ACR members to the COVID-19 pandemic. The only place for free North American stock rankings incorporating insider commitment. Efficacy and safety of deucravacitinib (BMS-986165), an oral, selective tyrosine kinase 2 inhibitor, in patients with active psoriatic arthritis: results from a phase 2, randomized, double-blind, placebo-controlled trial. A Delphi consensus study to standardize terminology for the pre-clinical phase of psoriatic arthritis. Zheni Stavre, MD; JungMin Kim, PhD; Jae-Hyuck Shim, PhD; Ellen M. Gravallese, MD. There were several interesting abstracts presented at this year’s ACR annual meeting from a therapy standpoint, some of which were also presented at the 2020 European League Against Rheumatism (EULAR) annual meeting. A couple of head-to-head studies were published in the past year, although not presented at ACR 2020, which compared ixekizumab vs adalimumab and secukinumab vs adalimumab. Neither of these agents was found to be effective in patients with axial spondyloarthritis (SpA). The ACR and NPF guidelines are very practical, and they answer exactly this question. Here is a flavour of my read through … Presented at: ACR Convergence 2020; November 5-9, 2020. Efficacy and safety of upadacitinib versus placebo and adalimumab in patients with active psoriatic arthritis and inadequate response to non-biologic disease-modifying anti-rheumatic drugs: a double-blind, randomized controlled phase 3 trial. This is where the treatment guidelines are very important. 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